- 2000September Established the Company
- October Launched the "MR-kun" service
- 2002March Acquired medical information website "WebMD Japan" from WebMD Japan, Inc.
- August Launched the "Research-kun" survey service Re-named "WebMD Japan" to "So-netm3.com"
- 2003January Acquired medical information website "MediPro/MyMediPro" from Sony Communications Network Corporation (currently So-net Entertainment Corporation)
- February Launched "MR-kun eCSO," a pharmaceutical product online promotion service integrated with MR-kun
- July Launched "m3.com", a medical information website composed of merged content from "MyMediPro" and "So-netm3.com"
- October Established So-net M3 USA Corporation (currently M3 USA Corporation)
- November Launched the "m3 MT" promotion service
- 2004April Launched "m3.com CAREER", a job search service for doctors
- September Listed on Tokyo Stock Exchange Mothers Market (IPO)
- 2005June Alliance with Medi C&C Co., Ltd. (Korea)
- September Listed on Tokyo Stock Exchange Mothers Market (IPO)
- December Launched "AskDoctors", M3's first B-to-C service
- 2006June Acquired MDLinx, Inc. (USA)
- 2007March Listed on Tokyo Stock Exchange First Section
- June Acquired iTICKET Corporation
- 2009March Merged So-net M3 USA Corporation and MDLinx, Inc.
- April Acquired Mebix, Inc.
- December Established M3 Career, Inc.
- 2010January Changed company name to M3, Inc.
- 2011August Acquired Doctors.net.uk Limited (UK)
